I haven’t tried doing that, but it would definitely be possible. You won’t have out of the box support for X-related configuration like you do on NixOS though.

If you give it a shot, please let me know how you go.

More or less, yep. It is integrated well though. For instance, you configure the terminal font with your nix config instead of setting it in the termux theme app.

Another daily driver user here (for about a year now). NixOS on all hardware that can run it (desktop, servers). Nix-darwin/home-manager/nix-on-droid everywhere else.

I don’t see myself going back to anything else, it’s great.